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Our pilot experiments confirmed an earlier study, reporting that the concentration of paclitaxel in plasma of mice remained very low after oral drug. Poor pharmacokinetic properties, including absorption, distribution, metabolism, excretion, and toxicity (admet), are the key reasons of late-. In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation. Bioavailability refers to the extent a substance or drug becomes completely available to its intended biological destination(s). It has been confirmed that the ultra-low oral bioavailability is due to poor gastrointestinal permeability, extensive pre-absorption degradation. Drugs with very low oral bioavailability (p20%). Bioavailability is expressed as the percentage of the total drug dose administered that reaches the circulation. For a drug taken orally, the 'first-pass effect. 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